Regio- and Stereoselective Rhodium(II)-Catalyzed C–H Functionalization of Organosilanes by Donor/Acceptor Carbenes Derived from Aryldiazoacetates

• DOI: 10.1021/acs.orglett.9b01833
• Publication Date: 2019-06-11T12:51:46Z
• Authors: Zachary J. Garlets; Elliot F. Hicks; Jiantao Fu; Eric A. Voight; Huw M. L. Davies
• Keywords: 01 natural sciences; 0104 chemical sciences

The regioselective and enantioselective intermolecular sp3 C-H functionalization of silicon-substituted alkanes with aryl diazoacetates was accomplished using the recently developed dirhodium catalyst Rh2( S-TPPTTL)4. These reactions generate a diverse array of stereodefined substituted silacycloalkanes with high enantioselectivity and diastereoselectivity.