Copper-Catalyzed Aldol Reaction of Vinyl Azides with Trifluoromethyl Ketones

• DOI: 10.1021/acs.orglett.9b02616
• Publication Date: 2019-09-11T12:30:41Z
• Authors: Zhenhua Liu; Zhihai Zhang; Guangyu Zhu; Yiqin Zhou; Lin Yang; Wen Gao; Lili Tong; Bo Tang
• Keywords: 01 natural sciences; 0104 chemical sciences

A novel and efficient aldol reaction of readily available vinyl azides with trifluoromethyl ketones by copper catalysis is developed. The reaction is proposed to go through a nucleophilic trapping of vinyl azides with trifluoromethyl ketones as a trifluoromethyl source, leading to the assembly of diverse trifluoromethylated compounds under mild conditions in satisfactory yield.