Alterbrassinoids A–D: Fusicoccane-Derived Diterpenoid Dimers Featuring Different Carbon Skeletons from Alternaria brassicicola

• DOI: 10.1021/acs.orglett.9b03133
• Publication Date: 2019-10-01T14:17:07Z
• Authors: Fengli Li; Shuang Lin; Sitian Zhang; Xincai Hao; Xiao-Nian Li; Beiye Yang; Junjun Liu; Jianping Wang; Zhengxi Hu; Yonghui Zhang
• Keywords: Alternaria brassicicola

Alterbrassinoids A-D (1-4), the first examples of fusicoccane-derived diterpenoid dimers furnished by forming an undescribed C-12-C-18' linkage, were isolated from modified cultures Alternaria brassicicola. Compounds 1 and 2 represent unprecedented heterodimers, whereas 3 4 homodimers, also features anhydride motif. Their structures assigned via spectroscopic methods, electronic circular dichroism calculations, single-crystal X-ray diffraction. Putative biosynthetic pathways a bioactivity evaluation for 1-4 discussed.