Aroylchlorination of 1,6-Dienes via a Photoredox Catalytic Atom-Transfer Radical Cyclization Process

• DOI: 10.1021/acs.orglett.9b03222
• Publication Date: 2019-10-15T13:05:08Z
• Authors: Quan-Sheng Zhao; Guo-Qiang Xu; Hui Liang; Zhu-Yin Wang; Peng-Fei Xu
• Keywords: 01 natural sciences; 0104 chemical sciences

A method using aroyl chlorides as atom-transfer radical cyclization agents in a novel visible-light photocatalytic aroylchlorination reaction is developed. The overall transformation involves the formation of two new C-C bonds and one new C-Cl bond in a one-pot process. The advantages of this reaction include high atom/step/redox economy, mild conditions, operational simplicity, and broad substrate scopes.