Ligand-Controlled Regiodivergent Hydroformylation of Ynamides: A Stereospecific and Regioselective Access to 2- and 3-Aminoacroleins

• DOI: 10.1021/acs.orglett.9b03566
• Publication Date: 2019-10-18T14:02:14Z
• Authors: Patrick Wagner; Morgan Donnard; Nicolas Girard
• Keywords: Carbonylation; Stereospecificity; Alkyne; Zanamivir

The rhodium-catalyzed hydroformylation of ynamides is described and gives selective access to 2- or 3-aminoacrolein derivatives. regioselectivity this carbonylation can be completely controlled at will thanks the nature ligand used. This represents first example regiodivergent alkyne hydroformylation. influence substituents on different positions ynamide has been investigated, it appears that reaction tolerant a wide range functional groups.