CuSO4-Catalyzed Tandem C(sp3)–H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

• DOI: 10.1021/acs.orglett.9b03751
• Publication Date: 2019-12-30T17:47:35Z
• Authors: Xiang-Huan Shan; Mei-Mei Wang; Lin Tie; Jian-Ping Qu; Yan-Biao Kang
• Keywords: Tandem; Cascade reaction

A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides practical modular synthesis N-aryl indoles from isonitriles.