Practical Synthesis of Benzimidazo[1,2-a]quinolines via Rh(III)-Catalyzed C–H Activation Cascade Reaction from Imidamides and Anthranils

• DOI: 10.1021/acs.orglett.9b04256
• Publication Date: 2019-12-30T15:26:56Z
• Authors: Yao Hu; Ting Wang; Yanzhao Liu; Ruifang Nie; Ninghong Yang; Qiantao Wang; Guo-Bo Li; Yong Wu
• Keywords: Cascade reaction; Reaction conditions; Scope (computer science)

We report a novel and practical one-pot Rh(III)-catalyzed strategy to construct benzimidazo[1,2-a]quinolines from readily available imidamides anthranils. The cascade reaction proceeds via C–H amination–cyclization–cyclization process in ionic liquid without any additives possesses simple operation, moderate-to-high yield, broad substrate scope features, which will provide the reference for construction of biologically active fused benzimidazoles.