Photoredox Oxo-C(sp3)–H Bond Functionalization via in Situ Cu(I)-Acetylide Catalysis

• DOI: 10.1021/acs.orglett.9b04277
• Publication Date: 2020-01-09T16:46:05Z
• Authors: Zi-Qi Song; Zan Liu; Qi-Chao Gan; Tao Lei; Chen-Ho Tung; Li-Zhu Wu
• Keywords: Acetylide; Surface Modification; Triple bond

A unified strategy for the synthesis of 2-vinyl heterocycles is reported. With visible light irradiation, simple and cheap CuCl able to functionalize a terminal alkyne, giving Cu(I)-acetylide in situ. Unlike case noble metals or organic dye photocatalysts, this critical not only activates C-H bond alkynes but also serves as photocatalyst achieve varieties good excellent yields, even large scale late-stage functionalization natural product.