Clearable Black Phosphorus Nanoconjugate for Targeted Cancer Phototheranostics

• DOI: 10.1021/acsami.0c02718
• Publication Date: 2020-03-30T17:07:36Z
• Authors: Deblin Jana; Shaorui Jia; Anivind Kaur Bindra; Pengyao Xing; Dan Ding; Yanli Zhao
• Keywords: Folate receptor; Biocompatibility; Black Phosphorus; Nanodot; Biocompatible material

Therapeutic efficacy of synergistic photodynamic therapy (PDT) and photothermal (PTT) is limited by complex conjugation chemistry, absorption wavelength mismatch, inadequate biodegradability the PDT–PTT agents. Herein, we designed biocompatible copper sulfide nanodot anchored folic acid-modified black phosphorus nanosheets (BP-CuS-FA) to overcome these limitations, consequently enhancing therapeutic efficiency PDT–PTT. In vitro in vivo assays reveal good biocompatibility commendable tumor inhibition BP-CuS-FA nanoconjugate because PTT–PDT mediated near-infrared laser irradiation. Importantly, acid unit could target folate receptor overexpressed cancer cells, leading enhanced cellular uptake BP-CuS-FA. also exhibits significant contrast effect for photoacoustic imaging, permitting its tracking. The photodegradable character associated with better renal clearance after antitumor vivo. present research may facilitate further development on straightforward approaches targeted imaging-guided cancer.