Dual-Stimuli-Responsive Multifunctional Gd2Hf2O7 Nanoparticles for MRI-Guided Combined Chemo-/Photothermal-/Radiotherapy of Resistant Tumors

• DOI: 10.1021/acsami.0c09422
• Publication Date: 2020-07-20T15:48:56Z
• Authors: Ye Kuang; Ye Zhang; Yuewu Zhao; Yi Cao; Yajie Zhang; Yu Chong; Renjun Pei
• Keywords: Drug Carriers; Integrins; Indoles; Contrast Media; Metal Nanoparticles; Mice, Nude; Antineoplastic Agents; Gadolinium; Hyperthermia, Induced; 02 engineering and technology; Combined Modality Therapy; Magnetic Resonance Imaging; 3. Good health; Drug Liberation; Mice; Drug Therapy; Drug Resistance, Neoplasm; Animals; Humans; Female; Cisplatin; 0210 nano-technology; Hafnium

The design and synthesis of a novel generation nanoscaled platform with imaging-guided therapy remain real challenge. It can not only improve the imaging sensitivity tumor tissues for guiding all kinds treatments but also reduce harm healthy tissues. Here, polydopamine (PDA), polyethylene glycol (PEG), c(RGDyK) peptide (RGD)-modified cisplatin-loaded Gd2Hf2O7 nanoparticles (Gd2Hf2O7@PDA@PEG-Pt-RGD NPs) are designed magnetic resonance (MRI)-guided combined chemo-/photothermal-/radiotherapy resistant tumors. as-prepared NPs display high relaxivity (r1 = 38.28 mM–1 s–1) as an MRI contrast agent because their ultrasmall size surface modification polyacrylic acid PDA. Gd2Hf2O7@PDA@PEG-Pt-RGD exhibit pH NIR dual-stimuli responsiveness cisplatin release. Based on competent absorption X-ray attenuation efficiency, show potential photothermal effect by exposing to 808 nm laser significantly reactive oxygen species after radiation. Combined effectively treat A549R cells, providing enhanced therapeutic efficiency cancer reduced side Furthermore, present no obvious toxicity during treatment, which demonstrates efficient MRI-guided nanoplatform drug-resistant