Targeted and Intracellular Antibacterial Activity against S. agalactiae of the Chimeric Peptides Based on Pheromone and Cell-Penetrating Peptides

• DOI: 10.1021/acsami.0c12226
• Publication Date: 2020-09-14T12:38:20Z
• Authors: Jiawei Li; Lu Shang; Jing Lan; Shuli Chou; Xingjun Feng; Baoming Shi; Jiajun Wang; Yinfeng Lyu; Anshan Shan
• Keywords: Magainin

The significance of the complex bacterial ecosystem in human body and impediment mammalian membrane against many antibiotics together emphasize necessity to develop antimicrobial agents with precise cell-penetrating activities. A simple feasible method for generating dual-function peptides inspired by highly hydrophobic peptide pheromone cationic is presented. Furthermore, extension candidate library achieved modifying charged domain. bacteria-selective L1, L2, L10, L11 kill Streptococcus agalactiae disrupting structure, targeted mechanism suggested where offset entrapment S. rather than other bacteria. Moreover, L2 L10 possess intracellular antibacterial activity carrier property, which mainly dependent on endocytosis. Given their suitable biocompatibility, high tolerance, no drug resistance, effective capacity a mouse mastitis model, can be powerful weapons pathogen infection.