Plasmonic Metasurfaces Based on Pyramidal Nanoholes for High-Efficiency SERS Biosensing

• DOI: 10.1021/acsami.1c12525
• Publication Date: 2021-09-01T16:27:06Z
• Authors: Giovanna Palermo; Massimo Rippa; Ylli Conti; Ambra Vestri; Riccardo Castagna; Giovanna Fusco; Elisabetta Suffre...; Jun Zhou; Joseph Zyss; Antonio De Luca; Lucia Petti
• Keywords: Surface-Enhanced Raman Spectroscopy

An inverted pyramidal metasurface was designed, fabricated, and studied at the nanoscale level for development of a label-free pathogen detection on chip platform that merges nanotechnology surface-enhanced Raman scattering (SERS). Based integration synergy these ingredients, virus immunoassay proposed as relevant proof concept very sensitive hepatitis A virus, first time to our best knowledge, in small volume (2 μL), without complex signal amplification, allowing detect minimal concentration 13 pg/mL. The work aims develop high-flux high-accuracy spectroscopy (SERS) nanobiosensor pathogens provide an effective method early easy water monitoring, which can be fast convenient.