Biodegradable Hollow Polydopamine@manganese Dioxide as an Oxygen Self-Supplied Nanoplatform for Boosting Chemo-photodynamic Cancer Therapy

• DOI: 10.1021/acsami.1c18601
• Publication Date: 2021-11-22T13:56:10Z
• Authors: Haiyang Wang; Wenbo Wang; Lu Liu; Meng Wang; Guowei Li; Hang Li; Bo Li; Siming Yu; Dong Ma; Wei Xue
• Keywords: Tumor Hypoxia

Photodynamic therapy (PDT) has attracted extensive attention in the clinical treatment of malignant tumor. However, acidic and hypoxic conditions tumor microenvironment (TME) limit further application PDT clinic. Herein, we fabricate a new nanoplatform─HPDA@MnO2@Ce6/DOX@PEG-RGD (HPMRCD)─by means coating hollow polydopamine nanoparticles (HPDA) with manganese dioxide (MnO2), which is modified by cyclic RGD functionalized poly(ethylene glycol) (PEG) co-loaded photosensitizer, Chlorin e6 (Ce6), chemotherapy drug, doxorubicin (DOX). This nanoplatform could be enriched tissues, then instantly dissociated under an H2O2-rich TME. The dual-responsive release Mn2+ ions oxygen (O2) can relieve hypoxia, used as magnetic resonance contrast agent latter enhance effect. Furthermore, degradation HPMRCD leads to efficient loaded therapeutic molecule release, thus yielding potential suppression adopting combined chemo-photodynamic therapy.