Fc Domain-Imprinted Stealth Nanogels Capable of Orientational Control of Immunoglobulin G Adsorbed In Vivo

• DOI: 10.1021/acsami.2c01953
• Publication Date: 2022-03-30T17:03:22Z
• Authors: Natsuki Hayakawa; Yukiya Kitayama; Kazunori Igarashi; Yu Matsumoto; Eri Takano; Hirobumi Sunayama; Toshifumi Takeuchi
• Keywords: Nanomaterials

Regulation of nanomaterial-cell interaction is an important requisite for a variety biomedical applications such as drug delivery systems and theranostics. Here, we demonstrate the regulation using oriented adsorption intrinsic immunoglobulin G (IgG) on molecularly imprinted polymer nanogels (MIP-NGs) capable recognizing fragment crystallizable (Fc) domain IgG. The unique recognition property resulted in suppression immune response Fc receptor-possessing macrophages natural killer cells due to protein corona based This hindrance domain, which trigger response. Furthermore, acquisition stealth capability was successfully demonstrated vivo intravital confocal laser scanning microscopy. imprinting proposed this study will provide new strategy creating nanomaterials recognition-based proteins situ, thus regulating formed nanomaterials. Thus, domain-recognition nanomaterial developed our can be used various target specific without triggering