Biofunctionalization of 3D Printed Porous Tantalum Using a Vancomycin–Carboxymethyl Chitosan Composite Coating to Improve Osteogenesis and Antibiofilm Properties

• DOI: 10.1021/acsami.2c11715
• Publication Date: 2022-09-10T15:41:01Z
• Authors: Tuozhou Liu; Wenbin Liu; Liyi Zeng; Zhongchi Wen; Zixuan Xiong; Zhan Liao; Yihe Hu
• Keywords: Biocompatibility; Gelatin

3D-printed porous tantalum scaffold has been increasingly used in arthroplasty due to its bone-matching elastic modulus and good osteoinductive ability. However, the lack of antibacterial ability makes it difficult for prevent occurrence development periprosthetic joint infection. The difficulty high cost curing infection (PJI) revision surgery limit further clinical application tantalum. Therefore, we fabricated vancomycin-loaded scaffolds by combining chemical grafting (3-aminopropyl)triethoxysilane (APTES) electrostatic assembly carboxymethyl chitosan vancomycin first time. Our vitro experiments show that achieves rapid killing initially adherent bacteria effectively prevents biofilm formation. In addition, our modification preserves original excellent structure biocompatibility promotes generation mineralized matrix osteogenesis-related gene expression mesenchymal stem cells on surface scaffolds. Through a rat subcutaneous model, composite bioscaffold shows efficient bacterial clearance inflammation control soft tissue creates an immune microenvironment suitable repair at early stage. Combined with economic friendliness practicality preparation, this great potential treatment