Osteo-Immunomodulatory Role of Interleukin-4-Immobilized Plasma Immersion Ion Implantation Membranes for Bone Regeneration

• DOI: 10.1021/acsami.2c17005
• Publication Date: 2023-01-06T14:56:31Z
• Authors: Fei Wei; Yuqing Mu; Richard P. Tan; Steven G. Wise; Marcela M. Bilek; Yinghong Zhou; Yin Xiao
• Keywords: Plasma-immersion ion implantation

Barrier membranes for guided tissue regeneration are essential bone repair and regeneration. The implanted may trigger early inflammatory responses as a foreign material, which can affect the recruitment differentiation of cells during purpose this study was to determine whether immobilizing interleukin 4 (IL4) on plasma immersion ion implantation (PIII)-activated surfaces alter osteo-immunoregulatory characteristics produce pro-osteogenic effects. In order immobilize IL4, polycaprolactone were modified using PIII technology. No discernible alterations found between morphology before after treatment or IL4 immobilization. IL4-immobilized polarized macrophages an M2 phenotype mitigated cytokine production under lipopolysaccharide stimulation. Interestingly, co-culture (on surfaces) marrow-derived mesenchymal stromal enhanced angiogenic osteogenic factors triggered autophagy activation. Exosomes produced by + IL4-stimulated also play role in osteoblast differentiation. conclusion, properties materials be PIII-assisted immobilization, creating favorable osteoimmune milieu