Bioengineered Bacterial Membrane Vesicles with Multifunctional Nanoparticles as a Versatile Platform for Cancer Immunotherapy

• DOI: 10.1021/acsami.2c18244
• Publication Date: 2023-01-11T17:57:07Z
• Authors: Xin Zheng Liu; Zhi Juan Wen; Yun Meng Li; Wan Ru Sun; Xiao Qian Hu; Jia Zhi Zhu; Xin Yu Li; Ping Yu Wang; José Luis Pedraz; Jung-Hwan Lee; Hae-Won Kim; Murugan Ramalingam; Shuyang Xie; Ranran Wang
• Keywords: Tumor Hypoxia; Cancer Immunotherapy

Inducing immunogenic cell death (ICD) is a critical strategy for enhancing cancer immunotherapy. However, inefficient and risky ICD inducers along with tumor hypoxia microenvironment seriously limit the immunotherapy efficacy. Non-specific delivery also responsible this inefficiency. In work, we report drug-free bacteria-derived outer membrane vesicle (OMV)-functionalized Fe3O4-MnO2 (FMO) nanoplatform that realized neutrophil-mediated targeted photothermally enhanced system, modification of OMVs derived from Escherichia coli accumulation FMO NPs at tissue through delivery. The underwent reactive decomposition in site, generating manganese iron ions induced O2 regulated environment. Moreover, are rich pathogen-associated pattern molecules can overcome immunosuppressive effectively activate immune cells, thereby specific responses. Photothermal therapy (PTT) caused by MnO2 Fe3O4 not only indirectly stimulate systemic immunity directly destroying cells but promote enrichment neutrophil-equipped nanoparticles inflammatory response site. Finally, proposed multi-modal treatment system capability effective to prevent growth recurrence.