A Highly Sensitive and Specific Photonic Crystal-Based Opioid Sensor with Rapid Regeneration

• DOI: 10.1021/acsami.3c03722
• Publication Date: 2023-05-30T15:46:39Z
• Authors: So Hee Nah; Daisy Unsihuay; Ping Wang; Shu Yang
• Keywords: Analgesics, Opioid; Fentanyl; Optics and Photonics; Morphine Derivatives; Humans; Biosensing Techniques; 3. Good health

Opioid misuse and overdose have caused devastating public health challenges economic burdens, calling for the need of rapid, accurate sensitive opioid sensors. Here, we report a photonic crystal-based sensor in total internal reflection configuration, providing label-free, quantitative measurements through change refractive index. The one-dimensional crystal with defect layer that is immobilized antibodies acts as resonator an open microcavity. highly accessible structure responds to analytes within minute after aqueous solution introduced, achieving highest sensitivity 5688.8 nm/refractive index unit (RIU) at incident angle 63.03°. Our shows limit detection (LOD) 7 ng/mL morphine phosphate-buffered saline (PBS, pH 7.4) solutions, well below required clinical limit, LOD 6 fentanyl PBS, close requirement. can selectively detect from mixture be regenerated 2 min up 93.66% recovery rate five cycles. efficacy our further validated artificial interstitial fluid human urine samples.