Molecular Docking-Guided Design on Glucose-Responsive Nanoparticles for Microneedle Fabrication and “Three-Meal-per-Day” Blood-Glucose Regulation

Blood Glucose Molecular Docking Simulation Glucose Drug Delivery Systems Polymers Animals Insulin Nanoparticles Rats Diabetes Mellitus, Experimental
DOI: 10.1021/acsami.3c06483 Publication Date: 2023-06-20T17:25:38Z
ABSTRACT
It was greatly significant, but difficult, to develop stimulus-responsive polymeric nanoparticles with efficient protein-loading and protein-delivering properties. Crucial obstacles were the ambiguous protein/nanoparticle-interacting mechanisms and the corresponding inefficient trial-and-error strategies, which brought large quantities of experiments in design and optimization. In this work, a molecular docking-guided universal "segment-functional group-polymer" process was proposed to simplify the previous laborious experimental step. The insulin-delivering glucose-responsive polymeric nanoparticles for diabetic treatments were taken as the examples. The molecular docking study obtained insights from the insulin/segment interactions. It was then experimentally confirmed in six functional groups for insulin-loading performances of their corresponding polymers. The optimization formulation was further proved effective in blood-glucose stabilization on the diabetic rats under the "three-meal-per-day" mode. It was believed that the molecular docking-guided designing process was promising in the protein-delivering field.
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