Multifunctional Carbon Quantum Dots: Iron Clearance and Antioxidation for Neuroprotection in Intracerebral Hemorrhage Mice

• DOI: 10.1021/acsami.3c13580
• Publication Date: 2023-12-01T16:03:02Z
• Authors: Xinyu Yang; Xiaolong Tang; Guangyu Jia; Ye Wang; Li Yang; Yuanyuan Li; Miaojing Wu; Zhe Zhang; Yamei Yu; Yao Xiao; Xingen Zhu; Shiyong Li

Iron overload and oxidative stress are pivotal in the pathogenesis of brain injury secondary to intracerebral hemorrhage (ICH). There is a compelling need for agents that can chelate iron scavenge free radicals, particularly those demonstrate substantial penetration, mitigate ICH-related damage. In this study, we have engineered an amine-functionalized aspirin-derived carbon quantum dot (NACQD) with nominal diameter 6–13 nm. The NACQD possesses robust iron-binding antioxidative capacities. Through intrathecal administration, therapy substantially reduced deposition tissue, alleviated meningeal inflammatory responses, improved recovery neurological function murine ICH model. As proof concept, injection promising therapeutic strategy ameliorate injury.