Nordihydroguaiaretic Acid-Cross-Linked Phenylboronic Acid-Functionalized Polyplex Micelles for Anti-angiogenic Gene Therapy of Orthotopic and Metastatic Tumors

• DOI: 10.1021/acsami.4c05311
• Publication Date: 2024-06-27T12:09:29Z
• Authors: Tangna Hao; Bingning Zhang; Wenjing Li; Xianxian Yang; Sha Wu; Yujie Yuan; Hongxia Cui; Qixian Chen; Zhen Li
• Keywords: Nordihydroguaiaretic acid; Phenylboronic acid

Polyplexes are required to be equipped with multiple functionalities accomplish adequate structure stability and gene transfection efficacy for therapy. Herein, a 4-carboxy-3-fluorophenylboronic acid (FPBA)-functionalized block copolymer of PEG-