Molecularly Imprinted Wearable Sensor with Paper Microfluidics for Real-Time Sweat Biomarker Analysis

• DOI: 10.1021/acsami.4c10033
• Publication Date: 2024-08-23T17:42:44Z
• Authors: Mayank Garg; Heng Guo; Ethan Maclam; Elizabeth Zhanov; Sathwika Samudrala; Anton Pavlov; Md Saifur Rahman; Myeong Namkoong; Jennette P. Moreno; Limei Tian
• Keywords: Molecularly imprinted polymer

The urgent need for real-time and noninvasive monitoring of health-associated biochemical parameters has motivated the development wearable sweat sensors. Existing electrochemical sensors show promise in analysis various chemical biomarkers. These often rely on labels redox probes to generate amplify signals detection quantification analytes with limited sensitivity. In this study, we introduce a molecularly imprinted polymer (MIP)-based sensor quantify molecular biomarker using impedance spectroscopy, which eliminates or probes. biosensor can achieve sensitive specific cortisol at concentrations as low 1 pM, 1000-fold lower than previously reported MIP We integrated multimodal an iontophoresis extraction module paper microfluidics analysis. Several be simultaneously quantified, including volume, secretion rate, sodium ion, concentration. Paper microfluidic modules not only volume rate but also facilitate continuous without user intervention. While focus sensing proof-of-concept, extended other biochemicals, such protein biomarkers therapeutic drugs.