Cerium Oxide Nanoparticles-Reinforced GelMA Hydrogel Loading Bone Marrow Stem Cells with Osteogenic and Inflammatory Regulatory Capacity for Bone Defect Repair

• DOI: 10.1021/acsami.4c15718
• Publication Date: 2024-11-25T17:07:41Z
• Authors: Ruideng Wang; Xi He; Jinwu Bai; Shilong Su; Rubing Zhou; Shan Gao; Haifeng Liu; Fang Zhou

Effective bone defect repair has been a tough clinical challenge due to the complexity of microenvironment. Hydrogels loaded with marrow mesenchymal stem cells (BMSCs) have widely applied for regeneration. However, low survival BMSCs at site transplantation and lack sufficient osteogenic induction capacity greatly limit their applications. In order solve this puzzle, we fabricated gelatin methacryloyl (GelMA) hydrogels containing cerium oxide (CeO