Integration of Graphene into Calcium Phosphate Coating for Implant Electronics

• DOI: 10.1021/acsami.4c21046
• Publication Date: 2025-02-19T14:15:30Z
• Authors: Elizaveta Dogadina; Raul D. Rodriguez; Maxim Fatkullin; Anna Lipovka; Anna Kozelskaya; Andrey Averkiev; Evgenii Plotnikov; Xin Jia; Chaozong Liu; Jin-Ju Chen; Chong Cheng; Li Qiu; Sergei Tverdokhlebov; Evgeniya Sheremet

Bone injuries remain a significant challenge, driving the development of new materials and technologies to enhance healing. This study presents novel approach for incorporating graphene into calcium phosphate (CaP) coatings on titanium alloy (Ti) substrates, with aim creating generation bone implant electronics. The stability composite coating under physiological conditions, long-term electrical mechanical durability, biocompatibility were systematically investigated. We integrated CaP through laser processing diazonium-functionalized films applied surface CaP-coated Ti. treatment induced several processes, including removal aryl groups, formation conductive pathways, chemical bonding film. As result, graphene-CaP nanocomposite demonstrated excellent withstanding 2 h sand abrasion test. It also exhibited biocompatibility, as shown by proliferation human fibroblast cells 7 days. properties remained stable conditions 12 weeks, material maintained electrochemical after 1 million pulse cycles. Furthermore, it withstood stress 100,000 bending cycles without compromising performance. work highlights versatility biocompatible its potential range applications free-form electronic circuits, electrodes, sensors, electrothermal heaters.