Co-Delivery of Cisplatin Prodrug and Chlorin e6 by Mesoporous Silica Nanoparticles for Chemo-Photodynamic Combination Therapy to Combat Drug Resistance

• DOI: 10.1021/acsami.6b03881
• Publication Date: 2016-05-10T18:42:40Z
• Authors: Wei Zhang; Jianliang Shen; Hua Su; Ge Mu; Jing-Hua Sun; Cai-Ping Tan; Xing-Jie Liang; Liang-Nian Ji; Zong-Wan Mao
• Keywords: Porphyrins; Chlorophyllides; Light; Drug Resistance; 02 engineering and technology; Silicon Dioxide; 3. Good health; Photochemotherapy; A549 Cells; Cell Line, Tumor; Humans; Nanoparticles; Prodrugs; Cisplatin; 0210 nano-technology

Combination therapy shows great promise in circumventing cisplatin resistance. We report herein the development of a novel nanoscale drug delivery system (nDDS) based nanotherapeutic that combines chemotherapy and photodynamic (PDT) into one single platform to achieve synergistic anticancer capacity conquer Mesoporous silica nanoparticle (MSNs) was used as vector conjugate prodrug load photosensitizer chlorin e6 (Ce6) afford dual loaded MSNs/Ce6/Pt. The hybrid nanoparticles have an average diameter about 100 nm slightly positive surface charge 18.2 mV. MSNs/Ce6/Pt can be efficiently internalized by cells through endocytosis, thereby achieving much higher cellular Pt uptake than cisplatin-resistant A549R lung cancer cells. After 660 light irradiation (10 mW/cm(2)), reactive oxygen species (ROS) level treated elevated dramatically. As result these properties, exhibited very potent activity against cells, giving half-maximal inhibitory concentration (IC50) value for combination 0.53 μM, lower (25.1 μM). This study suggests potential nDDS-based combined chemo-photodynamic circumvent