In Vitro and in Vivo Visualization and Trapping of Fluorescent Magnetic Microcapsules in a Bloodstream

• DOI: 10.1021/acsami.6b15811
• Publication Date: 2017-02-10T18:14:18Z
• Authors: Denis V. Voronin; Olga A. Sindeeva; Maxim A. Kurochkin; Oksana Mayorova; Ivan V. Fedosov; Oksana Semyachkin...; Dmitry A. Gorin; Valery V. Tuchin; Gleb B. Sukhorukov
• Keywords: Capsule; Ferrofluid

Remote navigation and targeted delivery of biologically active compounds is one the current challenges in development drug systems. Modern methods micro- nanofabrication give us new opportunities to produce particles capsules bearing cargo deploy possess magnetic properties be externally navigated. In this work we explore multilayer composite microcapsules as systems vitro vivo studies under natural conditions living organism. Herein, demonstrate addressing fluorescent with embedded magnetite nanoparticles blood flow environment. First, visualization capture at defined by field are shown an artificial glass capillary employing a wide-field fluorescence microscope. Afterward, visualized successfully trapped into exposed rat mesentery microvessels. Histological analysis shows that infiltrate small mesenteric vessels whereas large preserve microcirculation. The effect on capsule preferential localization bifurcation areas vasculature, including retention site once external magnet switched off discussed. research outcome demonstrates can effectively addressed flow, which makes them promising system remote field.