Peptide-Functionalized Nanomaterials for the Efficient Isolation of HER2-Positive Circulating Tumor Cells

• DOI: 10.1021/acsami.7b03905
• Publication Date: 2017-05-19T10:15:46Z
• Authors: Jiaxi Peng; Qiong Zhao; Wangshu Zheng; Wenzhe Li; Ping Li; Ling Zhu; Xiaoran Liu; Bin Shao; Huiping Li; Chen Wang; Yanlian Yang
• Keywords: Nanomaterials; Circulating tumor cell

The detection of circulating tumor cells (CTCs) with a specific antigen expression is necessary in therapeutic response monitoring and targeted therapy guidance. existence human epidermal growth factor receptor 2 (HER2) the concentration HER2-positive CTCs are strong indicators for patient diagnosis, prognosis, monitoring. Herein we report direct isolation by peptide-functionalized nanomaterials. We designed screened out peptide as an HER2 antibody alternative demonstrating high affinity selectivity. This recognition bound efficiently at ligand-binding domain. Efficient CTC capture were demonstrated using magnetic nanoparticles functionalized peptide.