Investigation of Controlled Growth of Metal–Organic Frameworks on Anisotropic Virus Particles

• DOI: 10.1021/acsami.8b01369
• Publication Date: 2018-03-19T18:49:16Z
• Authors: Shaobo Li; Madushani Dharmar...; Raymond P. Welch; Candace E. Benjamin; Alexandra M. Shamir; Steven O. Nielsen; Jeremiah J. Gasse...
• Keywords: Zeolitic imidazolate framework; Biomolecule

Biomimetic mineralization with metal–organic frameworks (MOF), typically zeolitic imidazolate framework-8 (ZIF-8), is an emerging strategy to protect sensitive biological substances against denaturing environmental stressors such as heat and proteolytic agents. Additionally, this same biomimetic process has the potential of being used create distinct core–shell architectures using genetically or chemically modified viral nanoparticles. Despite proliferation examples for ZIF-8 growth on proteinaceous substrates, systematic studies these processes are few far between. Herein, we employed tobacco mosaic virus (TMV) a model template investigate ZIF-8, which been proven be robust MOF encasing protecting inlaid substances. Our study shows dependence upon crystallization parameters, e.g., ligand metal molar ratio concentration, can yield several morphologies TMV@ZIF-8 composites phases ZIF-8. Further investigation charged synthetic conjugates, time dependent analysis, calorimetric analysis shown that TMV–Zn interaction plays pivotal role in final morphology TMV@ZIF-8, take form either bionanoparticles large crystals entrapped TMV located exclusively outer facets. The design rules outlined here, it hoped, will provide guidance MOFs materials