Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

• DOI: 10.1021/acsami.8b02246
• Publication Date: 2018-03-19T16:47:28Z
• Authors: Michal M. Dykas; Stuti K. Desai; Abhijeet Patra; Mallikarjuna Rao ...; Kingshuk Poddar; Linda J. Kenney; T. Venkatesan
• Keywords: Salmonella enterica; Deposition

With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that common human pathogen, Salmonella enterica serovar Typhimurium. We discovered library constructed using two oxides, net effect modeled as addition activities individual oxides weighted their relative composition at particular point library. contrast, similar three there was nonlinear relation between amount dominant and biofilms. This nonlinearity resulted useful combinations were not expected from average predictions. Our application will lead discovery additional alternatives creating antimicrobial surfaces.