Reductive-Responsive, Single-Molecular-Layer Polymer Nanocapsules Prepared by Lateral-Functionalized Pillar[5]arenes for Targeting Anticancer Drug Delivery

• DOI: 10.1021/acsami.8b03534
• Publication Date: 2018-04-17T15:39:05Z
• Authors: Shuang Fu; Yue Zhang; Shuwen Guan; Qiaoxian Huang; Ruibing Wang; Ruizhen Tian; Mingsong Zang; Shanpeng Qiao; Xin Zhang; Shengda Liu; Xiaotong Fan; Xiumei Li; Quan Luo; Chunxi Hou; Jiayun Xu; Zeyuan Dong; Junqiu Liu
• Keywords: Nanocapsules; Biocompatibility; Pillar; Smart polymer; Targeted drug delivery; Internalization; Layer by layer

Herein, a new reductive-responsive pillar[5]arene-based, single-molecule-layer polymer nanocapsule is constructed for drug delivery. The functionalized system shows good biocompatibility, efficient internalization into targeted cells and obvious triggered release of entrapped drugs in reducing environment such as cytoplasm. Besides, this smart vehicle loaded with anticancer excellent inhibition tumor cell proliferation exhibits low side effect on normal cells. This work not only demonstrates the development single molecular layer targeting delivery but also extends design materials biomedical applications.