Microenvironment-Responsive Magnetic Nanocomposites Based on Silver Nanoparticles/Gentamicin for Enhanced Biofilm Disruption by Magnetic Field

• DOI: 10.1021/acsami.8b10972
• Publication Date: 2018-09-21T22:55:18Z
• Authors: Xi Wang; Juan Wu; Peili Li; Lina Wang; Jie Zhou; Gaoke Zhang; Xin Li; Bingcheng Hu; Xiaodong Xing
• Keywords: Nanocarriers; Silver nanoparticle

Biofilms contribute to persistent bacterial infections as well formidable resistances conventional antibiotics. However, it is still a major challenge establish an advanced antibacterial nanoplatform that can efficiently eradicate biofilms while overcoming resistances. Taking advantage of the stimuli-responsive technique and magnetic guidance strategy, here we present highly efficient for planktonic inactivation biofilm disruption. The multilayer films consisting antibiotic gentamicin (Gen), tannic acid, silver nanoparticles (AgNPs) were fabricated coated on via electrostatic interactions. To achieve controlled drug release improved biocompatibility, biodegradable hyaluronic acid was capped outer surface responsive shell. In vitro profiles suggested nanocomposites showed both enzyme pH-responsive properties. could be employed powerful nanocarrier small molecular Gen AgNPs delivery on-demand in response infection microenvironment. also satisfying capacities against Gram-positive Staphylococcus aureus Gram-negative Escherichia coli. Intriguingly, with field navigation (NdFeB, 2000 gauss), guided handily penetrate into S. performed dual-responsive release, showing significantly enhanced Moreover, excess reactive oxygen species production resulting from contributed decomposition matrix ultimate eradication. As consequence, ingenious promising combating extra environmental factors such field.