Facile Fabrication of Magnetic Microrobots Based on Spirulina Templates for Targeted Delivery and Synergistic Chemo-Photothermal Therapy

• DOI: 10.1021/acsami.8b15586
• Publication Date: 2019-01-14T16:38:12Z
• Authors: Xu Wang; Jun Cai; Lili Sun; Shuo Zhang; De Gong; Xinghao Li; Shuhua Yue; Lin Feng; Deyuan Zhang
• Keywords: Photothermal effect; Targeted drug delivery; Nanorobotics

Magnetic microrobots can be actuated in fuel-free conditions and are envisioned for biomedical applications related to targeted delivery therapy a minimally invasive manner. However, mass fabrication of with precise propulsion performance excellent therapeutic efficacy is still challenging, especially predictable controllable Herein, we propose facile technique production magnetic multiple functions using Spirulina ( Sp.) as biotemplate. Core-shell-structured Pd@Au nanoparticles (NPs) were synthesized Sp. cells by electroless deposition, working photothermal conversion agents. Subsequently, the Fe3O4 NPs deposited onto surface obtained (Pd@Au)@ particles via sol-gel process, enabling them magnetically actuated. Moreover, anticancer drug doxorubicin (DOX) was loaded on (Pd@Au)/Fe3O4@ microrobots, which endows additional chemotherapeutic efficacy. The as-prepared biohybrid Sp.-DOX not only possess efficient highest speed 526.2 μm/s under rotating field but also have enhanced synergistic chemo-photothermal Furthermore, they structurally disassembled into individual near-infrared (NIR) laser irradiation exhibit pH- NIR-triggered release. These intriguing properties enable very promising platform loading, delivery, therapy.