Integrating 3D Printing and Biomimetic Mineralization for Personalized Enhanced Osteogenesis, Angiogenesis, and Osteointegration

• DOI: 10.1021/acsami.8b17495
• Publication Date: 2018-12-03T19:56:27Z
• Authors: Limin Ma; Xiaolan Wang; Naru Zhao; Ye Zhu; Zhiye Qiu; Qingtao Li; Ye Zhou; Zefeng Lin; Xiang Li; Xiaolong Zeng; Hong Xia; Shizhen Zhong; Yu Zhang; Yingjun Wang; Chuanbin Mao
• Keywords: Biocompatibility; Load bearing

Titanium (Ti) alloy implants can repair bone defects at load-bearing sites. However, they mechanically mismatch with the natural and lack customized adaption irregularly major-sized defects, resulting in failure of implant fixation. Mineralized collagen (MC), a building block bone, induce angiogenesis osteogenesis, 3D printing technology be employed to prepare scaffolds an overall shape defect. Hence, we induced formation MC, made hydroxyapatite (HAp) nanocrystals fibers, 3D-printed porous Ti6Al4V (PT) through situ biomimetic mineralization. The resultant MC/PT exhibited bone-like Young's modulus were anatomical contour actual rabbit model. We found that biocompatibility osteogenic differentiation are best when mass ratio between HAp fibers is 1 MC. then implanted into radius defect model significantly improved vascularized tissue integration new implants. Therefore, combination mineralization could lead PT for enhanced angiogenesis, osteointegration. Such represent novel patient-specific precisely repairing irregular defects.