Electropolymerized Poly(3,4-ethylenedioxythiophene) (PEDOT) Coatings for Implantable Deep-Brain-Stimulating Microelectrodes

• DOI: 10.1021/acsami.9b03088
• Publication Date: 2019-04-12T16:15:28Z
• Authors: Côme Bodart; Nicolò Rossetti; Jo’Elen Hagler; Pauline Chevreau; Danny Chhin; Francesca Soavi; Steen Brian Schou...; Florin Amzica; Fabio Cicoira
• Keywords: Poly(N-isopropylacrylamide)

Conducting polymers have been widely explored as coating materials for metal electrodes to improve neural signal recording and stimulation because of their mixed electronic–ionic conduction biocompatibility. In particular, the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) is one best candidates biomedical applications due its high conductivity good electrochemical stability. Coating with PEDOT has shown enhance electrode's performance by decreasing impedance increasing charge storage capacity. However, PEDOT-coated often issues delamination stability, resulting in decreased device lifetime. this work, we were able electropolymerize coatings on sharp platinum-iridium stimulating demonstrated mechanical Electropolymerization PEDOT:tetrafluoroborate was carried out three different solvents: propylene carbonate, acetonitrile, water. The stability assessed via ultrasonication, phosphate buffer solution soaking test, autoclave sterilization, electrical pulsing. Coatings prepared carbonate or acetonitrile possessed excellent survived prolonged soaking, without major changes properties. Stimulating microelectrodes implanted rats stimulated daily, 7 15 days. properties monitored vivo that procedure both coated uncoated impedance.