Photodynamic Bubble-Generating Microneedles for Enhanced Transdermal Cancer Therapy

• DOI: 10.1021/acsapm.1c01219
• Publication Date: 2021-12-01T13:17:25Z
• Authors: Xiaoyu Ning; Si Chen; Yating Yang; Jangsun Hwang; Christian Wiraja; Chi Zhang; Wei Liu; Linbo Liu; Chenjie Xu
• Keywords: Penetration (warfare); Ex vivo

Active bubble-generating microneedles (MNs) upon skin interstitial fluid (ISF) contact facilitate deeper and more efficient delivery of intradermal therapeutics. However, MN platforms are sensitive to moisture, which limits their variety load various functional drugs. This article presents a frozen immersion method that facilitates both hydrophobic hydrophilic drug loading onto MNs without compromising properties. The formed bubbles ISF induce distinct vortex flow produces propulsion force enhance transportation. efficiency transdermal is further enhanced by sonophoresis. this platform first evaluated ex vivo using fresh mouse skins human keloid tissues. Later, in the tumor-bearing model, enhances penetration photosensitizers (i.e., methylene blue) correspondingly improves efficacy photodynamic therapy.