Dynamically and Spatially Controllable Albumin-Based Hydrogels for the Prevention of Postoperative Adhesion

• DOI: 10.1021/acsbiomaterials.1c00363
• Publication Date: 2021-06-21T20:41:52Z
• Authors: Syuan-Yu Mao; Hui-Wen Peng; Shih-Yen Wei; Chi-Shuo Chen; Ying-Chieh Chen
• Keywords: Biomaterial

Since the degree of severity and geometry wounds vary, it is necessary to prepare an antiadhesive hydrogel that possesses dynamically controllable material properties, exhibits biodegradability, drug-releasing properties. Injectable, oxygen peroxide-sensitive, photo-cross-linkable hydrogels permit in situ dynamic spatial control their physicochemical properties were synthesized for prevention postoperative adhesion. Albumin most abundant protein blood serum serves as a carrier several molecules exhibit poor water solubility. It therefore suitable biomaterial fabrication since presents low risk life-threatening complications does not require immunosuppressive therapy preventing graft rejection. The this can then be spatially postadjusted via transdermal exposure light release drugs, depending on what required injury. A significant reduction peritoneal adhesion was observed animal model involving severe sidewall bowel abrasions. This study demonstrated fabricated dually cross-linked, albumin-based have great potential such applications because they showed immune response, easy handling, full wound coverage, tunable biodegradability. Precise drug-release profiles may also achieved post-tuning biomaterials,