Combination of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Provides Potential Biomarkers for Early-Stage Parkinson’s Disease

• DOI: 10.1021/acschemneuro.2c00321
• Publication Date: 2022-09-01T13:26:40Z
• Authors: Yunjie Rong; Zhifeng Xu; Ye Zhu; Xianhai Zhang; Lingfeng Lai; Shuyi Sun; Mingyong Gao; Pi Guo; Guohua Zhang; Yiqun Geng; Xilun Ma; Shuohua Wu; Lin Yang; Zhiwei Shen; Jitian Guan
• Keywords: Quantitative Susceptibility Mapping; Putamen; Kurtosis; Caudate nucleus; Subthalamic Nucleus

Purpose: This study aimed to detect changes in iron deposition and neural microstructure the substantia nigra (SN), red nucleus (RN), basal ganglia of Parkinson's disease (PD) patients at different stages using quantitative susceptibility mapping diffusion kurtosis imaging identify potential indicators early-stage PD. Methods: We enrolled 20 15 late-stage PD patients, as well age- sex-matched controls. All participants underwent determine magnetic (MS), fractional anisotropy (FA), mean diffusivity (MD), (MK) several brain regions. Results: Compared with control group, MS MK values SN were significantly increased early- whereas globus pallidus (GP), caudate (CN), FA value CN GP, putamen (PU) group. There positive correlations between GP. Furthermore, combination provided high accuracy for distinguishing from Conclusions: identified