An Efficient Synthesis of 2-Substituted Benzimidazoles via Photocatalytic Condensation of o-Phenylenediamines and Aldehydes

• DOI: 10.1021/acscombsci.6b00107
• Publication Date: 2016-09-15T19:17:01Z
• Authors: Jeshma Kovvuri; Burri Nagaraju; Ahmed Kamal; Ajay K. Srivastava
• Keywords: Rose bengal; Condensation reaction; Benzimidazole

A photocatalytic method has been developed for the efficient synthesis of functionalized benzimidazoles. This protocol involves condensation o-phenylenediamines with various aldehydes using Rose Bengal as photocatalyst. The was found to be general and successfully employed accessing pharmaceutically important benzimidazoles by aromatic, heteroaromatic aliphatic o-phenylenediamines, in good-to-excellent yields. Notably, effective less reactive heterocyclic o-phenylenediamines.