Highly Regioselective, Acid-Catalyzed, Three-Component Cascade Reaction for the Synthesis of 2-aminopyridine-Decorated Imidazo[1,2-a]pyridine

• DOI: 10.1021/acscombsci.8b00149
• Publication Date: 2019-01-17T17:37:08Z
• Authors: Qiu-Xing He; Yao-Feng Liang; Chang Xu; Xiao-Kun Yao; Hua Cao; Hua-Gang Yao
• Keywords: Aldehydes; Molecular Structure; Pyridines; Imidazoles; Solvents; Aminopyridines; Stereoisomerism; 01 natural sciences; Catalysis; 0104 chemical sciences

A highly regioselective acid-catalyzed three-component reaction of 2-aminopyridine and 3-phenylpropiolaldehyde for the construction of imidazo[1,2- a]pyridine has been developed. This strategy provides a broad range of substrates and represents an efficient approach to give various 2-aminopyridine-decorated imidazo[1,2- a]pyridine in good yields.