The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against Plasmodium falciparum

• DOI: 10.1021/acsinfecdis.4c00461
• Publication Date: 2024-08-15T02:52:57Z
• Authors: Savannah J. Watson; Mariëtte E. van d...; Anjo Theron; Janette Reader; Sizwe Tshabalala; Erica Erlank; Lizette L. Koekemoer; Mariska Naude; Marianna Stampolaki; Feyisola Adewole; Katie Sadowska; Pilar Pérez-Lozano; Andreea L. Turcu; Santiago Vázquez; Jihee Ko; Ben Mazurek; Davinder Singh; Satish R. Malwal; Mathew Njoroge; Kelly Chibale; Oluseye K. Onajole; Antonios Kolocouris; Eric Oldfield; Lyn-Marié Birkholtz
• Keywords: Trioxane; Chemotype; Lipophilicity

Toward repositioning the antitubercular clinical candidate SQ109 as an antimalarial, analogs were investigated for structure-activity relationships activity against asexual blood stages of human malaria parasite