Positron Emission Tomography Imaging of Acinetobacter baumannii Infection: Comparison of Gallium-68 Labeled Siderophores

• DOI: 10.1021/acsinfecdis.4c00946
• Publication Date: 2025-03-18T09:16:47Z
• Authors: Katerina Dvorakov...; Kristyna Krasulova; Barbora Neuzilova; Miroslav Popper; Patrik Mlynarcik; Katarina Hajduova; Zbynek Novy; Marian Hajduch; Milos Petrik
• Keywords: Acinetobacter baumannii

Acinetobacter baumannii (AB) is an opportunistic pathogen with growing clinical relevance due to its increasing level of antimicrobial resistance in the last few decades. In event AB hospital outbreak, fast detection and localization crucial, prevent further spread. However, contemporary diagnostic tools do not always meet requirements for rapid accurate diagnosis. For this reason, we report here possibility using gallium-68 labeled siderophores, bacterial iron chelators, positron emission tomography imaging infections. our study, radiolabeled several siderophores tested their vitro uptake cultures. Based on results properties studied selected two them vivo testing infectious models. Both ferrioxamine E ferrirubin, showed promising characteristics. vivo, observed pharmacokinetics no excessive accumulation organs other than excretory normal mice. We demonstrated that accumulate AB-infected tissue three animal models: a murine model myositis, dorsal wound infection rat pneumonia. These suggest both Ga-68 could be used PET infection.