Precisely Striking Tumors without Adjacent Normal Tissue Damage via Mitochondria-Templated Accumulation

• DOI: 10.1021/acsnano.8b03212
• Publication Date: 2018-05-23T17:42:29Z
• Authors: Zhaoyu Ma; Kai Han; Xinxin Dai; Heyou Han
• Keywords: Organelle

Ignored damage in adjacent normal tissue is fatal especially some specific tumor therapy such as brain tumors, but it remains a great challenge to conquer due random drug diffusion and complexity. Herein, we show that hyperthermia mitochondria, an interparticle plasmonic coupling effect activated nanoevent, selectively strikes tissues without damaging tissues. Spherical gold nanoparticles with mitochondria-targeting moiety, triphenyl phosphonium, preferentially accumulated inside mitochondria reached the threshold activate among nanoparticles, realizing selective light-thermal conversion mitochondrial dysfunction tumor, whereas little were observed In vivo study revealed temperature increment irradiation was nearly 4-fold tissue. This subcellular organelle-templated accumulation strategy provides therapeutic model for highly negligible local side effects.