Enhanced Hemocompatibility and Cytocompatibility of Stainless Steel

• DOI: 10.1021/acsomega.4c01191
• Publication Date: 2024-04-16T16:15:11Z
• Authors: Metka Benčina; Niharika Rawat; Domen Paul; Janez Kovač; Katja Lakota; Polona Žigon; Veronika Kralj-Iglič; Aleš Iglič; Ita Junkar
• Keywords: anodization; anatomy; blood platelets; electrochemical anodization; surface modifications, electrochemical anodization, non-thermal plasma treatment, altered surface properties, blood platelets, human coronary stents; human coronary stents; surface modifications; Chemistry; info:eu-repo/classification/udc/577; non-thermal plasma treatment; cells; altered surface properties; QD1-999; plasma; surface interactions

The present study introduces an advanced surface modification approach combining electrochemical anodization and non-thermal plasma treatment, tailored for biomedical applications on stainless steel grade 316L (SS316L) surfaces. Nanopores with various diameters (100-300 nm) were synthesized anodization, samples further modified oxygen plasma. properties of SS316L surfaces examined by scanning electron microscopy, atomic force X-ray photoemission spectroscopy, Water contact angle measurements. It has been shown that a combination treatment significantly alters the affects its interactions blood platelets human coronary cells. Optimal performance is attained anodized specimen featuring pores within 150-300 nm diameter range, subjected to subsequent treatment; absence platelet adhesion was observed. At same time, sample demonstrated good endothelialization reduction in smooth muscle cell compared untreated smaller (100-150 nm). This novel strategy significant implications improving biocompatibility applications.