Single Cell Mass Spectrometry Quantification of Anticancer Drugs: Proof of Concept in Cancer Patients

• DOI: 10.1021/acsptsci.0c00156
• Publication Date: 2021-01-06T02:24:40Z
• Authors: Ryan C. Bensen; Shawna J. Standke; Devon H. Colby; Naga Rama Kothapalli; Anh T. Le-McClain; Michael A. Patten; Abhishek Tripathi; Jonathan E. Heinlen; Zhibo Yang; Anthony W. G. Bur...
• Keywords: Drug Development

In clinical cancer medicine, the current inability to quantify intracellular chemotherapy drug concentrations in individual human cells limits personalization and overall effectiveness of administration. New bioanalytical methods capable real-time measurement levels live single would allow for more adaptive personalized administration drugs, potentially leading better outcomes with fewer side effects. this study, we report development a new quantitative cell mass spectrometry (qSCMS) method providing absolute amounts cells. Using qSCMS system, analysis gemcitabine present bladder is reported, including isolated from patients undergoing standard-of-care chemotherapy. The pharmacology can lead effective safely administered medications patients, especially treatment cancer.