Dual-Modality Detection of Early-Stage Drug-Induced Acute Kidney Injury by an Activatable Probe

• DOI: 10.1021/acssensors.0c00640
• Publication Date: 2020-07-24T08:47:30Z
• Authors: Lingyan Liu; Liping Jiang; Wei Yuan; Zhongkuan Liu; Dongya Liu; Peng Wei; Xinyu Zhang; Tao Yi
• Keywords: Pharmaceutical Preparations; Humans; Acute Kidney Injury; 01 natural sciences; Fluorescence; Fluorescent Dyes; Hypochlorous Acid; 0104 chemical sciences

Early detection of drug-induced acute kidney injury (AKI) is crucial for effective treatment and prevention further injury. It remains challenging, however, because the lack activatable indicators with multimodality imaging capability that could increase accuracy diagnosis by mutual verification. Herein, we report an probe, FDOCl-22, enabled dual-modality early-stage AKI. FDOCl-22 was completely soluble in water highly sensitive to hypochlorous acid (HOCl). Dramatic increases both near-infrared (NIR) emission absorption were observed after reaction HOCl. A correlation between HOCl concentration AKI established using as a tool. As consequence, HOCl-activated probe able detect imaging, irrespective drug stimulation time or dosage, combining NIR fluorescence photoacoustic imaging.