Noninvasive Diagnosis of Gastric Cancer Based on Breath Analysis with a Tubular Surface-Enhanced Raman Scattering Sensor

• DOI: 10.1021/acssensors.2c00146
• Publication Date: 2022-05-13T19:09:19Z
• Authors: Liping Huang; Yajie Zhu; Changshun Xu; Yu Cai; Yongdong Yi; Kang Li; Xueqian Ren; Danfeng Jiang; Yuancai Ge; Xiaohu Liu; Weijian Sun; Qingwen Zhang; Yi Wang
• Keywords: Breath gas analysis

SERS-based breath analysis as an emerging technique has attracted increasing attention in cancer screening. Here, eight aldehydes and ketones the human are reported VOC biomarkers identified by gas chromatography–mass spectrometry (GC-MS) applied further for noninvasive diagnosis of gastric (GC) with a tubular SERS sensor. The sensor is prepared glass capillary loaded ZIF-67-coated silver particles (Ag@ZIF-67), which offers Raman enhancement from plasmonic nanoparticles enrichment metal–organic framework (MOF) shells. composite materials modified 4-aminothiophenol (4-ATP) to capture different aldehyde ketone compounds. served simultaneously flow channel detection chamber, bringing higher efficiency than planar As proof-of-concept, successfully employed screen patients accuracy 89.83%, based on noninvasive, rapid, easily operated analysis. results demonstrate that established method provides excellent alternative screening GC other diseases.