Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection

• DOI: 10.1021/acssensors.3c00228
• Publication Date: 2023-05-08T19:08:07Z
• Authors: Ying Li; Chiao-Chun Chang; Chu Wang; Wen-Ti Wu; Chih-Min Wang; Hsiung-Lin Tu
• Keywords: Dopamine; Microfluidics; Reproducibility of Results; Biosensing Techniques; Indium; Phosphates

Developing functional materials that directly integrate into miniaturized devices for sensing applications is essential constructing the next-generation point-of-care system. Although crystalline structure such as metal organic frameworks are attractive exhibiting promising potential biosensing, their integration limited. Dopamine (DA) a major neurotransmitter released by dopaminergic neurons and has huge implications in neurodegenerative diseases. Integrated microfluidic biosensors capable of sensitive monitoring DA from mass-limited samples thus significant importance. In this study, we developed systematically characterized biosensor functionalized with hybrid material composed indium phosphate polyaniline nanointerfaces detection. Under flowing operation, displays linear dynamic range going 10–18 to 10–11 M limit detection (LOD) value 1.83 × 10–19 M. addition high sensitivity, sensor showed good selectivity toward stability (>1000 cycles). Further, reliability practical utility were demonstrated using neuro-2A cells treated activator, promoter, inhibiter. These results underscore importance integrated advanced systems.