Iontronic Photoelectrochemical Biorecognition Probing

• DOI: 10.1021/acssensors.3c02544
• Publication Date: 2024-01-23T06:17:17Z
• Authors: Hang Dong; Hai-Yan Wang; Yi-Tong Xu; Xian Zhang; Hong-Yuan Chen; Jing-Juan Xu; Wei-Wei Zhao
• Keywords: Bioconjugation

Herein, the first iontronic photoelectrochemical (PEC) biorecognition probing is devised by rational engineering of a dual-functional bioconjugate, i.e., light-sensitive intercalated structural DNA, as smart gating module confined within nanotip, which could respond to both incident light and biotargets interest. Light stimulation bioconjugate intensify negative charge at nano-orifice sustain enhanced ionic current. The presence proteins (e.g., acetylcholinesterase, AChE) or nucleic acids microRNA (miR)-10b) lead release with altered signaling. practical applicability methodology confirmed AChE detection in human serum miR-10b single cells.