Electrochemical Sensor for the Detection and Accurate Early Diagnosis of Ovarian Cancer

• DOI: 10.1021/acssensors.3c02776
• Publication Date: 2024-05-22T19:44:47Z
• Authors: Feng Ge; Wei Ding; Cong Han; Limin Zhang; Qirui Liu; Jian Zhao; Zhaofeng Luo; Chao Jia; Pengpeng Qu; Liyun Zhang

Ovarian cancer (OC) has the highest mortality rate among malignant tumors, primarily because it is difficult to diagnose early. Exosomes, a type of extracellular vesicle rich in parental information, have garnered significant attention field diagnosis and treatment. They play an important regulatory role occurrence, development, metastasis OC. Consequently, exosomes emerged as noninvasive biomarkers for early detection. Therefore, identifying cancer-derived may offer novel biomarker detection In this study, we developed metal–organic frameworks assembled "double hook"-type aptamer electrochemical sensor, which enables accurate Under optimal experimental conditions, impedance spectroscopy technology demonstrated good linear relationship within concentration range 31–3.1 × 106 particles per microliter, with limit low 12 microliter. The universal exosome platform constructed, can not only differentiate between high-grade serous ovarian (HGSOC) patients healthy individuals but also distinguish HGSOC nonhigh-grade OC (non-HGSOC). provides strategy holds great significance clinical differential diagnosis.