Plug-In Design of the Microneedle Electrode Array for Multi-Parameter Biochemical Sensing in Gouty Arthritis

• DOI: 10.1021/acssensors.4c01595
• Publication Date: 2025-01-09T12:23:22Z
• Authors: Zhibo Liu; Xinshuo Huang; Zhengjie Liu; Shantao Zheng; Chuanjie Yao; Tao Zhang; Shuang Huang; Junrui Zhang; Jizhuang Wang; Shady Farah; Xi Xie; Hui-jiuan Chen
• Keywords: Gouty arthritis; Inflammatory arthritis

Gouty arthritis is one of the most common forms inflammatory and has brought a significant burden on patients society. Current strategies for managing gout primarily focus long-term urate-lowering therapy. With rapid advancement point-of-care testing (POCT) technology, continuous monitoring gout-related biomarkers like uric acid (UA) or cytokines can provide personalized diagnosis management. In this study, plug-in design microneedle electrode array (PIMNA) was developed integrated into multi-parameter sensing portable system in combination with embedded circuits mobile application. The enabled real-time, situ, dynamic biomarkers, including UA, reactive oxygen species (ROS), pH at gouty joints. demonstrated wide linear response range, excellent selectivity, stability, reproducibility, reliable signal transmission performance. vivo experiments real-time capability PIMNA ROS, pH, showing potential to facilitate management inflammation assessment. Prospectively, enables quantitative analysis complexity diversity gout, presenting promising applications clinical practice. This work provides unique strategy broader arthritic disease treatment.